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Easy Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce

Creamy Cajun Chicken Spaghetti

This creamy Cajun chicken spaghetti blends tender spiced chicken with a rich garlic mozzarella sauce, delivering a comforting, cheesy, and mildly spicy pasta perfect for any dinner occasion.
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Prep Time 15 minutes
Cook Time 30 minutes
Total Time 45 minutes
Course Main Course, pasta
Cuisine cajun
Servings 6 people
Calories 640 kcal

Equipment

  • 1 large skillet for cooking chicken and sauce
  • 1 large pot for cooking spaghetti

Ingredients
  

  • 1 pound boneless skinless chicken breasts, cut into bite-sized pieces
  • 2 tablespoons olive oil
  • 2 tablespoons Cajun seasoning
  • 1 teaspoon smoked paprika
  • 1 pound spaghetti
  • 4 tablespoons butter
  • 4 cloves garlic minced
  • 1/4 cup all-purpose flour
  • 3 cups whole milk
  • 1 cup chicken broth
  • 8 ounces cream cheese softened
  • 2 cups shredded mozzarella cheese divided
  • 1/2 cup grated Parmesan cheese
  • Salt and freshly ground black pepper to taste
  • Optional: red pepper flakes for extra heat

Instructions
 

  • Cook spaghetti in salted water according to package instructions until al dente. Drain and set aside.
  • Season chicken pieces with Cajun seasoning and smoked paprika.
  • Heat olive oil in a large skillet over medium-high heat. Add chicken and cook until browned and cooked through, about 6 to 8 minutes. Remove chicken and set aside.
  • In the same skillet, melt butter over medium heat. Add minced garlic and sauté for 1 minute until fragrant.
  • Sprinkle flour into the skillet and whisk continuously for 1 to 2 minutes to form a roux.
  • Gradually whisk in milk and chicken broth, stirring constantly to prevent lumps. Bring the mixture to a gentle simmer.
  • Add cream cheese and 1 cup of mozzarella cheese, stirring until melted and smooth.
  • Stir in Parmesan cheese, then season the sauce with salt, black pepper, and red pepper flakes if using.
  • Return the cooked chicken to the sauce and simmer for 2 to 3 minutes to heat through.
  • Add the cooked spaghetti to the skillet and toss to coat in the sauce.
  • Sprinkle the remaining 1 cup of mozzarella cheese over the pasta, cover, and let sit for 2 to 3 minutes until the cheese melts.
  • Serve hot, optionally garnished with fresh parsley or extra Parmesan.

Notes

  • Use rotisserie or leftover chicken for a quicker version.
  • Substitute spaghetti with fettuccine, linguine, or penne.
  • Adjust spice by changing Cajun seasoning and red pepper flakes amounts.
  • Store leftovers in the fridge up to 3 days and reheat gently.