Cook the ground beef in a skillet over medium heat until fully browned, then drain excess fat.
Season the beef with garlic powder, onion powder, salt, pepper, and Worcestershire sauce if using.
Remove from heat and mix in shredded cheddar and softened cream cheese until combined.
Preheat the oven to 375 °F (190 °C).
Flatten each biscuit dough piece into a 4-inch circle.
Place about 2 tablespoons of the beef mixture in the center of each dough circle.
Pinch the edges together tightly to form a sealed ball.
Combine melted butter, minced garlic (or garlic powder), and Parmesan cheese in a bowl.
Brush the garlic-Parmesan butter generously over each dough ball.
Place the bombs seam-side down on a parchment-lined baking sheet.
Bake for 12–15 minutes until golden brown and cooked through.
Allow to cool for a few minutes. Optionally garnish with chopped parsley before serving.
Serve warm with dipping sauces such as ketchup, ranch, or spicy mayo.