Preheat the oven to 350°F and spray a 9x13-inch baking dish with nonstick spray.
In a medium bowl, whisk together the cream of mushroom soup, milk, and chopped parsley; set aside.
In a large bowl, combine ground beef, crushed saltines, milk, Italian seasoning, garlic powder, onion powder, paprika, cayenne pepper, salt, and pepper.
Mix the ingredients until combined, then gently form into even-sized patties.
Place flour in a shallow dish and season it with salt and pepper; dredge each patty in the flour.
Heat butter and olive oil in a large skillet over medium-high heat. Sear patties on both sides until golden brown, working in batches.
Transfer browned patties to the prepared baking dish, then pour the mushroom gravy evenly over them. Cover with aluminum foil.
Bake in the preheated oven for 30 to 40 minutes, or until patties are cooked through.