Preheat oven to 375°F (190°C).
In a large bowl, combine ground beef, chopped onion, cilantro, jalapeño, garlic, cumin, chili powder, smoked paprika, salt, and pepper.
Add shredded cheddar cheese and crushed tortilla chips, mixing thoroughly.
Pour beaten egg into mixture and mix well to bind ingredients.
Form mixture into golf-ball-sized meatballs using your hands.
Heat olive oil in an ovenproof skillet over medium heat.
Sear meatballs in skillet until browned on all sides, about 5 minutes.
Pour Mexican-style tomatoes with green chilies over meatballs in skillet.
Transfer skillet to oven and bake meatballs for 15-20 minutes until cooked through.
Serve hot with fresh lime wedges for garnish.