Split each chicken breast into two even cutlets and season both sides with a mixture of garlic powder, onion powder, Cajun seasoning, and paprika.
Marinate the seasoned chicken cutlets in a mixture of buttermilk and hot sauce, submerged and refrigerated for at least 30 minutes.
Preheat oven according to biscuit package instructions and bake the Pillsbury Homestyle biscuits until golden brown; let rest.
In a skillet over medium-high heat, cook breakfast sausage, breaking it apart; sprinkle flour and stir to coat.
Gradually add half and half while stirring constantly; cook 5-7 minutes until gravy thickens; season with salt and pepper.
Remove chicken from marinade, coat evenly in flour mixed with Cajun seasoning, then fry in hot vegetable oil (350°F) until golden and cooked through, about 3-5 minutes per side.
Drain fried chicken on paper towels to remove excess oil.
Slice each biscuit in half, place fried chicken on the bottom half, spoon sausage gravy over the chicken, and top with the biscuit halves.
Serve immediately while hot.