Prepare seafood by peeling and deveining shrimp, patting scallops dry, and cutting fish into 1-inch pieces.
Sauté shrimp and scallops in 1 tablespoon unsalted butter over medium heat until pink, 1-2 minutes, then remove and set aside.
If using fish like cod, poach in water or broth until it flakes easily or add raw to sauce; cook mussels if included and remove meat from shells.
Combine all seafood in a bowl and season with salt and black pepper.
In a medium saucepan, melt 4 tablespoons butter over medium heat and whisk in 1/4 cup flour to create a roux, cooking 1-2 minutes.
Slowly whisk in 2 cups milk and cook until sauce thickens and simmers, about 5-7 minutes.
Reduce heat to low and stir in shredded cheese, minced shallot, garlic, nutmeg, and white grape juice or broth.
Season sauce with salt, white pepper, and lemon juice.
Gently fold seafood into béchamel sauce and transfer to a shallow gratin dish.
In a small bowl, mix panko breadcrumbs, grated Parmesan, and chopped parsley, then sprinkle evenly over the gratin.
Dot the topping with small pieces of butter.
Bake in preheated oven at 375°F (190°C) for 20-30 minutes until bubbly and golden brown.
Allow gratin to rest 5-10 minutes before serving.